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Chemical Structure : SJ572946
Catalog No.: PC-20313Not For Human Use, Lab Use Only.
SJ572946 is a small molecule BAK activator, binds to the activation groove of BAK and selectively triggers BAK activation over that of BAX in liposome and mitochondrial permeabilization assays.
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SJ572946 is a small molecule BAK activator, binds to the activation groove of BAK and selectively triggers BAK activation over that of BAX in liposome and mitochondrial permeabilization assays.
In combination with apoptotic inducers and BH3 mimetics, SJ572946 kills experimental cancer cell lines.
SJ572946 also cooperates with the endogenous BAK activator BID in activating a misfolded BAK mutant substantially impaired in activation.
| M.Wt | 198.67 | |
| Formula | C8H7ClN2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Giridhar Sekar, et al. iScience. 2022 Sep 6;25(10):105064.
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