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Chemical Structure : SJB2-043
CAS No.: 63388-44-3
Catalog No.: PC-73197Not For Human Use, Lab Use Only.
SJB2-043 is a small molecule, specific USP1 inhibitor, inhibits USP1/UAF1 complex with IC50 of 0.544 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $428 | In stock | |
| 200 mg | $728 | In stock | |
| 1 g | Get quote |
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SJB2-043 is a small molecule, specific USP1 inhibitor, inhibits USP1/UAF1 complex with IC50 of 0.544 uM.
SJB2-043 is an inhibitor of the native USP1/UAF1 complex.
SJB2-043 promotes ID1 degradation and inhibits growth of the leukemic cell line K562, also causes a decrease in the levels of other ID proteins, namely ID2 and ID3.
SJB2-043 causes cytotoxicity in multiple AML cell line K562 with EC50 of 1.07 uM, and exhibits growth inhibition of primary AML cells from patients.
SJB2-043 increases the levels of Ub-FANCD2, decreases the HR activity, and sensitizes the cells to chemotherapy agents.
SJB2-043 also inhibits SARS-CoV-2 papain-like protease (PLpro) with IC50 of <10 uM.
| M.Wt | 275.26 | |
| Formula | C17H9NO3 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Mistry H, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62.
2. Chia-Chuan Cho, et al. ChemMedChem. 2022 Jan 5;17(1):e202100455.
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