SK2 channel inhibitor Compound 1

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Chemical Structure : SK2 channel inhibitor Compound 1

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Catalog No.: PC-25952Not For Human Use, Lab Use Only.

SK2 channel inhibitor Compound 1 is a potent, selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2) with IC50 of 69 nM, with 10-fold reduced potency for SK4 (IC50=660 nM), has high selectivity over other ion channels tested including hERG, Nav1.5, KCNQ1, and Cav1.2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	424.43
Formula	C20H16N4O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(benzo[c][1,2,5]oxadiazol-4-yl)-3-((4-methoxyphenyl)sulfonamido)benzamide

References

1. Cassell SJ, et al. Elife. 2025 Dec 4;14:RP107733.

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