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Chemical Structure : SKF-86002
CAS No.: 72873-74-6
Catalog No.: PC-43080Not For Human Use, Lab Use Only.
SKF-86002 is a potent inhibitor of p38 MAPK with IC50 of 0.5-1 uM, inhibits LPS-induced IL-1 and TNF-α production in human monocyte with IC50 of 1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $125 | In stock | |
| 25 mg | $325 | In stock | |
| 50 mg | $525 | In stock | |
| 250 mg | Get quote |
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SKF-86002 is a potent inhibitor of p38 MAPK with IC50 of 0.5-1 uM, inhibits LPS-induced IL-1 and TNF-α production in human monocyte with IC50 of 1 uM; inhibits prostaglandin H2 (PGH2) synthase activity (IC50=120 uM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50=70 uM); blocks superoxide anion production in response to FMLP and reduces adhesion and chemotaxis in response to PAF or FMLP in human neutrophils; also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50=10 and 100 uM respectively), shows anti-inflammatory in vivo.
| M.Wt | 297.35 | |
| Formula | C16H12FN3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Imidazo[2,1-b]thiazole, 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)- |
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1. Griswold DE, et al. Biochem Pharmacol. 1987 Oct 15;36(20):3463-70.
2. Nick JA, et al. J Clin Invest. 1997 Mar 1;99(5):975-86.
3. Lee JC, et al. Nature. 1994 Dec 22-29;372(6508):739-46.
4. Perregaux DG, et al. Mol Pharmacol. 1995 Sep;48(3):433-42.
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