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Chemical Structure : SKI-73
Catalog No.: PC-73099Not For Human Use, Lab Use Only.
SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors.
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SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors.
SKI-73 (10 uM) fully suppresses the methylation of BAF155 Arg1064 in MCF-7 cells.
SKI-73 inhibits in vitro invasion but not proliferation of breast cancer cells ( MDA-MB-231 cell, EC50=1.3 uM).
SKI-73 recapitulates the anti-invasion effect of the genetic perturbation of CARM1.
Either CARM1 knockout or CARM1 inhibition with SKI-73 alters the epigenetic plasticity in a proliferation-independent manner by replacing the most invasion-prone subpopulation with the non-invasive subpopulation(s) to suppress the invasive phenotype.
| M.Wt | 851.018 | |
| Formula | C46H58N8O8 | |
| Appearance | Solid | |
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1. Xiao-Chuan Cai, et al. Elife. 2019 Oct 28;8:e47110.
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