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Chemical Structure : SKLB188
Catalog No.: PC-61769Not For Human Use, Lab Use Only.
SKLB188 is a small molecule multikinase inhibitor and potently inhibits EGFR with IC50 of 5 nM.
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SKLB188 is a small molecule multikinase inhibitor and potently inhibits EGFR with IC50 of 5 nM.
SKLB188 inhibits a number of receptor tyrosine kinases, including Abl, Erb2, Erb4, Flt1, Flt3, Flt4, EphB, FGFR, c-Kit, Met, and PDGFR at 10 uM.
SKLB188 potently inhibits the growth of HNSCC cells in vitro and in vivo by targeting EGFR signalling.
SKLB188 inhibits FaDu xenograft growth in nude mice.
| M.Wt | 513.606 | |
| Formula | C27H31N9O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Barzegar M, et al. Br J Cancer. 2017 Sep 5. doi: 10.1038/bjc.2017.298.
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