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Chemical Structure : SM13
Catalog No.: PC-62499Not For Human Use, Lab Use Only.
SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
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SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
SM13 reduces cell proliferation and induces apoptosis in vitro in cells carrying either p53 WT or mutated gene, suggesting that its effect is independent from p53 transcriptional activity.
SM13 induces cancer cell death in a dose-dependent manner through the activation of the mitochondrial-dependent death signalling in p53-mutated cells.
SM13 reduces tumour growth in vivo.
| M.Wt | 481.405 | |
| Formula | C21H25BrN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sorriento D, et al. Br J Cancer. 2015 Jan 6;112(1):77-85.
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