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Chemical Structure : SMC-21598
CAS No.: 3392-07-2
Catalog No.: PC-49404Not For Human Use, Lab Use Only.
SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3.
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SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3.
SMC-21598 does not inhibit TGF-β, CXCL12, and EGF -induced cell migration.
SMC-21598 inhibited CCL18 induced cell migration in a concentration dependent manner with IC50 value of 130±70 nM for MDA-MB-231 cells.
SMC-21598 (10 uM) significantly inhibited CCL18-induced breast cancer cells adherence, invasiveness, and migration.
SMC-21598 did not significantly affect xenografts growth, but inhibited lung metastasis.
| M.Wt | 272.257 | |
| Formula | C11H16N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,5-dioxopyrrolidin-1-yl (tert-butoxycarbonyl)glycinate |
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1. Liu Y, et al. Clin Exp Metastasis. 2019 Jun;36(3):243-255.
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