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Chemical Structure : SNS-032
CAS No.: 345627-80-7
Catalog No.: PC-42052Not For Human Use, Lab Use Only.
SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 100 mg | $398 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.
SNS-032 (BMS-387032) displays 10- and 20-fold selective over CDK1/cycB and CDK4/cycD (IC50=480 and 925 nM) respectively, and a panel of unrelated kinases, respectively.
SNS-032 (BMS-387032) blocks the cell cycle via inhibition of CDKs 2 and 7, and transcription via inhibition of CDKs 7 and 9, has an A2780 cellular cytotoxicity assay IC50 of 95 nM.
SNS-032 (BMS-387032) exhibits a efficacy profile in A2780 human ovarian carcinoma xenograft model.
| M.Wt | 380.528 | |
| Formula | C17H24N4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Piperidinecarboxamide, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]- |
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1. Misra RN, et al. J Med Chem. 2004 Mar 25;47(7):1719-28.
2. Mukhopadhyay P, et al. Cancer Res. 2006 Feb 1;66(3):1758-66.
3. Chen R, et al. Blood. 2009 May 7;113(19):4637-45.
4. Heath EI, et al. Invest New Drugs. 2008 Feb;26(1):59-65.
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