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Chemical Structure : SOX11 inhibitor Compound E
Catalog No.: PC-38123Not For Human Use, Lab Use Only.
SOX11 inhibitor Compound E (SOX11i) is a small molecule inhibitor of SOX11, bind directly to SOX11-DBD and interfere with DNA binding.
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SOX11 inhibitor Compound E (SOX11i) is a small molecule inhibitor of SOX11, binds directly to SOX11-DBD and interfere with DNA binding.
SOX11 inhibitor Compound E (SOX11i) demosntrates SOX11-specific growth inhibition (IC50=12-15 uM) in SOX11-positive MCL cell lines (JeKo-1, Mino and Z-138).
SOX11 inhibitor Compound E (SOX11i) inhibits pBTK levels in all three SOX11+ cell lines (IC50=28-43 uM), no effect on pBTK level in SOX11-negative JVM-2 cells.
SOX11 belongs to the SOXC family of high mobility group (HMG) transcription factors, which consists of SOX4, SOX11, and SOX12.
SOX11 protein is expressed in the majority (78–93%) of MCL patients and is specific for MCL as compared to other types of Non-Hodgkin's Lymphoma (NHL).
| M.Wt | 487.973 | |
| Formula | C22H18ClN3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shashidhar S Jatiani, et al. Clin Cancer Res. 2021 Aug 15;27(16):4652-4663.
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