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Chemical Structure : SP-8008
Catalog No.: PC-47038Not For Human Use, Lab Use Only.
SP-8008 is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation.
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SP-8008 is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation.
SP‐8008 binds to von Willebrand factor (vWF) at the protein-protein interaction site and inhibits the binding of GP Ib through electrostatic and steric repulsion.
SP‐8008 selectively inhibited platelet aggregation under high shear stress conditions.
SP‐8008 (5-25 mg/kg, oral) exhibited highly potent antiplatelet and antithrombotic effects by selectively attenuating platelet activation and aggregation, induced by shear stress in vivo.
| M.Wt | 288.299 | |
| Formula | C16H16O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thien Ngo, et al. Br J Pharmacol. 2020 Feb;177(4):929-944.
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