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Chemical Structure : SP 141
CAS No.: 1253491-42-7
Catalog No.: PC-60462Not For Human Use, Lab Use Only.
A novel specific MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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SP 141 is a specific MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation.
SP 141 induces pancreatic cancer cell death (IC50=0.38-0.5 uM) and inhibits MDM2 expression, regardless of the p53 status of the cells.
SP 141 inhibits growth of xenograft tumors in vivo.
| M.Wt | 324.383 | |
| Formula | C22H16N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole |
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1. Wang W, et al. Gastroenterology. 2014 Oct;147(4):893-902.e2.
2. Qin JJ, et al. J Control Release. 2016 Sep 10;237:101-14.
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