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Chemical Structure : SP600125
CAS No.: 129-56-6
Catalog No.: PC-42856Not For Human Use, Lab Use Only.
SP600125 is a potent, selective, reversible, ATP-competitive inhibitor of JNK with IC50 of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $98 | In stock | |
| 100 mg | $148 | In stock | |
| 200 mg | $238 | In stock | |
| 1 g | Get quote |
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SP600125 (SP 600125) is a potent, selective, reversible, ATP-competitive inhibitor of JNK with IC50 of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively.
SP600125 displays 300-fold selectivity against related MAP kinases ERK1 and p38, and PKA.
SP600125 dose dependently inhibits the phosphorylation of c-Jun, the expression of inflammatory genes COX-2, IL-2, IFN-γ, TNF-α, and prevents the activation and differentiation of primary human CD4 cell cultures.
SP600125 blocks LPS-induced expression of TNF-α and inhibits anti-CD3-induced apoptosis of CD4+ CD8+ thymocytes in vivo model of endotoxin-induced inflammation.
| M.Wt | 220.2261 | |
| Formula | C14H8N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 45 mg/mL |
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| Chemical Name/SMILES |
Anthra[1,9-cd]pyrazol-6(2H)-one |
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1. Bennett BL, et al. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13681-6.
2. Han Z, et al. J Clin Invest. 2001 Jul;108(1):73-81.
3. Gee K, et al. J Immunol. 2002 Nov 15;169(10):5660-72.
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