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SPDP

Chemical Structure : SPDP

CAS No.: 68181-17-9

SPDP

Catalog No.: PC-42088Not For Human Use, Lab Use Only.

SPDP is a heterobifunctional crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls, used for PROTAC design.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SPDP is a heterobifunctional crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls, used for PROTAC design.

Physicochemical Properties

M.Wt 312.3647
Formula C12H12N2O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Propanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester

References

1. Woo BH, et al. Arch Pharm Res. 1994 Dec;17(6):452-7.

2. Lobedanz S, et al. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4612-7.

3. Ma G, et al. Int J Nanomedicine. 2013;8:1029-35.

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