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Chemical Structure : SPH5030
Catalog No.: PC-72266Not For Human Use, Lab Use Only.
SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants.
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SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants.
SPH5030 exhibits high relative HER2 selectivity compared with neratinib and pyrotinib.
SPH5030 shows significant in vivo antitumor efficacy in xenograft mouse models, especially in a HER2 mutation A775_G776insYVMA xenograft mouse mode.
| M.Wt | 582.61 | |
| Formula | C31H31FN8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Di Li, et al. Journal of Medicinal Chemistry March 23, 2022.
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