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Chemical Structure : SPI-21
Catalog No.: PC-73083Not For Human Use, Lab Use Only.
SPI-21 (Spt5-Pol II inhibitor 21) is a small-molecule inhibitor of Spt5-Pol II with IC50 of 25.2 uM.
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SPI-21 (Spt5-Pol II inhibitor 21) is a small-molecule inhibitor of Spt5-Pol II with IC50 of 25.2 uM.
Short-term SPI-21 treatment to HeLa cells caused a transcription upregulation (≥2-fold) of 1,371 genes, among them A20 (TNFAIP3), IL-6, IL-8 (CXCL8), and CCL20 (analyzed above), while CXCL2, IEX1 (IER3), and JUNB were unchanged.
SPI-21 precisely mimics the effect of Spt5 depletion on basal and activated NF-κB target genes and on the expanded repeat Htt gene.
Spt5 is a conserved and essential transcription elongation factor that promotes promoter-proximal pausing, promoter escape, elongation, and mRNA processing.
SPI-21 is a useful chemical probe to elucidate the function of Spt5.
| M.Wt | 270.284 | |
| Formula | C16H14O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bahat A, et al. Mol Cell. 2019 Nov 21;76(4):617-631.e4.
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