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Chemical Structure : SPRi3
Catalog No.: PC-61241Not For Human Use, Lab Use Only.
SPRi3 (SPR inhibitor 3) is a small molecule inhibitor of sepiapterin reductase (SPR) with IC50 of 74 nM in cell-free assays, efficiently reduces biopterin levels with IC50 of 5.2 uM.
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SPRi3 (SPR inhibitor 3) is a small molecule inhibitor of sepiapterin reductase (SPR) with IC50 of 74 nM in cell-free assays, efficiently reduces biopterin levels with IC50 of 5.2 uM; also significantly reduces SPR activity in mouse primary cultures of sensory neurons (IC50=0.45 uM) without affecting the activity of GCH1; reduces pain hypersensitivity effectively with a concomitant decrease in BH4 levels in target tissues, acting both on sensory neurons and macrophages, with no development of tolerance or adverse effects.
| M.Wt | 262.309 | |
| Formula | C14H18N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Latremoliere A, et al. Neuron. 2015 Jun 17;86(6):1393-406.
2. Cronin SJF, et al. Nature. 2018 Nov;563(7732):564-568.
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