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Chemical Structure : SQ-29548
Catalog No.: PC-20722Not For Human Use, Lab Use Only.
SQ-29548 (SQ-29,548) is a potent and specific antagonist of thromboxane-prostanoid (TP) receptor with binding Ki value of 4.1 nM.
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SQ-29548 (SQ-29,548) is a potent and specific antagonist of thromboxane-prostanoid (TP) receptor with binding Ki value of 4.1 nM.
SQ-29548 inhibits platelet aggregation induced by AA, the endoperoxide analog U-46,619 or collagen in platelet-rich plasma with IC50 of 0.8, 0.3 or 2.9 microM, respectively.
SQ-29548 does not affect ADP and platelet-activating factor acether-induced platelet aggregation, and thromboxane B2 formation.
SQ-29548 antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and venous smooth muscles with drug/receptor dissociation constants (KB) in the range of 0.5-1.7 nM.
| M.Wt | 387.48 | |
| Formula | C21H29N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. H Darius, et al. J Pharmacol Exp Ther. 1985 Nov;235(2):274-81.
2. Ogletree ML, et al. J Pharmacol Exp Ther. 1992.
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