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Chemical Structure : SR-16157
Catalog No.: PC-61433Not For Human Use, Lab Use Only.
A novel dual-acting steroid sulfatase inhibitor (IC50=0.1 uM) and selective ERα modulator (SERM).
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A novel dual-acting steroid sulfatase inhibitor (IC50=0.1 uM) and selective ERα modulator (SERM); exerts STS inhibition and antiestrogenic effects, 10 times more potent than the antiestrogens SR-16137 and tamoxifen in cell growth and ERα function test in MCF-7 breast cancer cells; displays profoundly improved ERα binding affinity and antiestrogenic effects on expression of estrogen-regulated genes.
Breast Cancer
Phase 2 Clinical
| M.Wt | 492.719 | |
| Formula | C27H44N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rasmussen LM, et al. Breast Cancer Res Treat. 2007 Dec;106(2):191-203.
2. Rausch L, et al. Cancer Chemother Pharmacol. 2011 Jun;67(6):1341-52.
3. Wang J, et al. J Pharm Biomed Anal. 2007 Nov 30;45(4):572-82.
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