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Chemical Structure : SR1001
CAS No.: 1335106-03-0
Catalog No.: PC-43525Not For Human Use, Lab Use Only.
SR1001 is a higly potent, specific, inverse agonist of both RORα and RORγt with binding Ki of 172 and 111 nM, does not binds RORβ and devoid of LXR activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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SR1001 is a higly potent, specific, inverse agonist of both RORα and RORγt with binding Ki of 172 and 111 nM, does not binds RORβ and devoid of LXR activity.
SR1001 inhibits the development of murine T(H)17 cells by inhibition of IL-17A gene expression and protein production, also inhibits the expression of cytokines when added to differentiated murine or human T(H)17 cells.
SR1001 modulates the expression of ROR target genes by decreasing coactivator recruitment (SRC2).
SR1001 effectively suppresses the clinical severity of autoimmune disease in mice.
| M.Wt | 477.40 | |
| Formula | C15H13F6N3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 39 mg/mL |
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| Chemical Name/SMILES |
Acetamide, N-[4-methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolyl]- |
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1. Solt LA, et al. Nature. 2011 Apr 28;472(7344):491-4.
2. Solt LA, et al. Endocrinology. 2015 Mar;156(3):869-81.
3. Beurel E, et al. Biol Psychiatry. 2013 Apr 1;73(7):622-30.
4. Ding Q, et al. BMC Immunol. 2015 May 29;16:32.
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