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Chemical Structure : SRC-3 inhibitor SI-10
Catalog No.: PC-20506Not For Human Use, Lab Use Only.
SRC-3 inhibitor SI-10 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 8.5 nM, exhibits low hERG activity (IC50>10 uM).
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SRC-3 inhibitor SI-10 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 8.5 nM, exhibits low hERG activity (IC50>10 uM).
SRC-3 inhibitor SI-10 (5–50 nM) can significantly inhibit viability, migration and invasion of breast cancer cells in vitro and repress the growth of breast cancer PDX organoids.
SRC-3 inhibitor SI-10 (10 mg/kg/day) was sufficient to repress growth of xenograft tumors derived from MDA-MB-231 and LM2 cells.
SRC-3 inhibitor SI-10 effectively inhibited progression of breast cancer lung metastasis in spontaneous and experimental metastasis mouse models developed from MDA-MB-231 and LM2 cells respectively.
| M.Wt | 302.29 | |
| Formula | C14H12F2N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li Qin, et al. Endocr Relat Cancer. 2021 Aug 13;28(10):657-670.
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