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Chemical Structure : SRP-001
Catalog No.: PC-20837Not For Human Use, Lab Use Only.
SRP-001 is a non-opioid and non-hepatotoxic small molecule ApAP analog, induces analgesia via N-arachidonoylphenolamine (AM404) formation, and generates higher amounts of AM404 than ApAP.
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SRP-001 is a non-opioid and non-hepatotoxic small molecule ApAP analog, induces analgesia via N-arachidonoylphenolamine (AM404) formation, and generates higher amounts of AM404 than ApAP.
SRP-001 is devoid of hepatotoxicity due to lack of NAPQI formation and protection of hepatic tight junctions integrity.
SRP-001 has comparable analgesia in pain models, including the complete Freund's adjuvant (CFA) inflammatory von Frey.
SRP-001 shows modulation of pain-related gene expression and cell signaling pathways, including the endocannabinoid, mechanical nociception, and fatty acid amide hydrolase (FAAH) pathways.
SRP-001 regulates the expression of key genes encoding FAAH, 2-AG, CNR1, CNR2, TRPV4, and voltage-gated Ca2+ channel.
| M.Wt | 405.47 | |
| Formula | C19H23N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hernan Bazan, et al. Res Sq. 2023 May 4;rs.3.rs-2883310.
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