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Chemical Structure : SRT 1720
CAS No.: 925434-55-5
Catalog No.: PC-42642Not For Human Use, Lab Use Only.
SRT 1720 is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SRT 1720 is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM.
SRT 1720 displays good selectivity for activation of SIRT1 versus SIRT2 (EC1.5=37 uM) and SIRT3 (EC1.5>300 uM).
SRT 1720 is 1,000-fold more potent than resveratrol.
SRT 1720 improves insulin sensitivity, lower plasma glucose, and increases mitochondrial capacity in obese mice model.
| M.Wt | 469.5614 | |
| Formula | C25H23N7OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Quinoxalinecarboxamide, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]- |
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1. Milne JC, et al. Nature. 2007 Nov 29;450(7170):712-6.
2. Pacholec M, et al. J Biol Chem. 2010 Mar 12;285(11):8340-51.
3. Funk JA, et al. J Pharmacol Exp Ther. 2010 May;333(2):593-601.
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