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SRT2104

Chemical Structure : SRT2104

CAS No.: 1093403-33-8

SRT2104 (GSK2245840)

Catalog No.: PC-47061Not For Human Use, Lab Use Only.

SRT2104 (GSK2245840) is a highly selective small molecule activator of the NAD+ dependent deacetylase SIRT1.

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Biological Activity

SRT2104 (GSK2245840) is a highly selective small molecule activator of the NAD+ dependent deacetylase SIRT1, increases Sirt1 protein with no effect on Sirt1 mRNA level.

Physicochemical Properties

M.Wt 516.638
Formula C26H24N6O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-methyl-N-[2-[3-(4-morpholinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-(3-pyridinyl)-5-thiazolecarboxamide

References

1. Ethan Hoffmann, et al. Br J Clin Pharmacol. 2013 Jan;75(1):186-96.

2. Mercken EM, et al. Aging Cell. 2014 Oct;13(5):787-96.

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