Chemical Structure : SSTC3
Catalog No.: PC-60387Not For Human Use, Lab Use Only.
SSTC3 is a novel small-molecule CK1α activator with EC50 of 30 nM (WNT-driven reporter gene assay), Kd of 32 nM.
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SSTC3 is a novel small-molecule CK1α activator with EC50 of 30 nM (WNT-driven reporter gene assay), Kd of 32 nM; has better pharmacokinetic properties than pyrvinium, attenuates the growth of such Apc mutant organoids with EC50 of 2.9 uM; decreases the viability of the WNT-dependent cell lines (EC50 = 132, 63, and 123 nM for HT29, SW403, and HCT116 cells, respectively), inhibits the growth of CRC xenografts in mice; also attenuates the growth of patient-derived metastatic CRC xenograft, with minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.
M.Wt | 518.529 | |
Formula | C23H17F3N4O3S2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Li B, et al. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916.
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