Chemical Structure : ST171
CAS No.:
ST171
(ST-171)
Catalog No.: PC-28376Not For Human Use, Lab Use Only.
ST171 (ST-171) is a potent, functionally selective agonist of 5-HT1A receptor (5-HT1AR) with Ki of 0.41 nM, has 680-fold subtype selectivity over 5-HT2AR and 8000-fold selectivity over 5-HT6R, selectively activates 5-HT1AR-mediated Gi/o signaling.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ST171 (ST-171) is a potent, functionally selective agonist of 5-HT1A receptor (5-HT1AR) with Ki of 0.41 nM, has 680-fold subtype selectivity over 5-HT2AR and 8000-fold selectivity over 5-HT6R, selectively activates 5-HT1AR-mediated Gi/o signaling.
ST171 inhibits cAMP accumulation with high efficacy and subnanomolar potency (EC50=0.88 nM).
ST171 functional selectivity for Gi/o over Gs, does not stimulate the recruitment of β-arrestin 1 or 2 to the 5-HT1AR.
ST171 also displays only moderate affinity, e.g., for the opioid receptor family (Ki > 5 μM) and α2A adrenergic receptors (Ki = 260 nM) in a set of 23 other class A GPCRs.
ST171 (10-20 mg/kg) reduces hypersensitivity in mouse models of chronic neuropathic and inflammatory pain.
Physicochemical Properties
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M.Wt
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372.42
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Formula
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C20H24N2O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-(3-((2-(2-methoxyphenoxy)ethyl)amino)propoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one
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References
1. Ullrich A, et al. Sci Adv. 2025 Jun 20;11(25):eadv9267.
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