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Chemical Structure : ST2 inhibitor XY52
Catalog No.: PC-21150Not For Human Use, Lab Use Only.
ST2 inhibitor XY52 is a specific small molecule inhibitor of soluble suppression of tumorigenesis-2 factor (ST2) with IC5 of 5.68 and 4.59 uM in ST2/IL-33 AlphaLISA and HEK-Blue reporter assays, repsectively.
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ST2 inhibitor XY52 is a specific small molecule inhibitor of soluble suppression of tumorigenesis-2 factor (ST2) with IC5 of 5.68 and 4.59 uM in ST2/IL-33 AlphaLISA and HEK-Blue reporter assays, repsectively.
ST2 inhibitor XY52 shows 11-fold selectivity over ST2/IL1RAcP(IC50=64.3 uM) in AlphaLISA assay, inhibits more effectively the binding of IL-33 with sST2 than membrane ST2 bound with IL1RAcP.
ST2 inhibitor XY52 shows improved inhibitory activity and metabolic stability in vitro and in vivo than iST2-1 (Cat# PC-35645).
ST2 inhibitor XY52 (5-10 uM) induces dose-dependent reduction in CD4+ and CD8+ T-cell proliferation, with no significant toxicity to human peripheral blood mononuclear cells (PBMCs).
ST2 inhibitor XY52 (40 mg/kg BID, i.p. 21 days) reduces plasma sST2 and IFN-γ levels and GVHD score and extends survival in mice graft versus host disease (GVHD) model.
| M.Wt | 499.66 | |
| Formula | C30H37N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xinrui Yuan , et al. ACS Pharmacol Transl Sci. 2023 Aug 16;6(9):1275-1287.
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