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Chemical Structure : STF-1084
CAS No.: 2298390-71-1
Catalog No.: PC-72236Not For Human Use, Lab Use Only.
STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM.
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|---|---|---|---|
| 2 mg | $358 | In stock | |
| 5 mg | $588 | In stock | |
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STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM.
STF-1084 has low activity towards the closely related ectonucleotidases alkaline phosphatase (Ki,app>100 μM) and ENPP2 (Ki,app=5.5 μM), as well as against a panel of 468 kinases.
STF-1084 (10 uM) could completely block extracellular cGAMP degradation in ENPP1 overexpressing 293T cGAS cells, without effect on intracellular cGAMP.
STF-1084 rescued extracellular cGAMP levels in the media and induction of IFNB1 expression in CD14+ cells, wothout effect on cytokine production when cGAMP was electroporated into primary human PBMCs.
| M.Wt | 381.369 | |
| Formula | C17H24N3O5P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl)ethyl)phosphonic acid |
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1. Jacqueline A Carozza, et al. Nat Cancer. 2020 Feb;1(2):184-196.
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