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STIMA 1

Chemical Structure : STIMA 1

CAS No.: 91634-12-7

STIMA 1 (STIMA1)

Catalog No.: PC-62083Not For Human Use, Lab Use Only.

STIMA 1 is a small molecule mutant p53 reactivator that can stimulate mutant p53 DNA binding in vitro, induces expression of p53 target proteins and triggers apoptosis in mutant p53-expressing human tumor cells..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

STIMA 1 is a small molecule mutant p53 reactivator that can stimulate mutant p53 DNA binding in vitro, induces expression of p53 target proteins and triggers apoptosis in mutant p53-expressing human tumor cells.

Physicochemical Properties

M.Wt 172.187
Formula C10H8N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-ethenyl-1H-quinazolin-4-one

References

1. Zache N, et al. Mol Oncol. 2008 Jun;2(1):70-80.

2. Bykov VJ, et al. FEBS Lett. 2014 Aug 19;588(16):2622-7.

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