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Chemical Structure : STM2457
CAS No.: 2499663-01-1
Catalog No.: PC-38285Not For Human Use, Lab Use Only.
STM2457 (STM-2457) is a highly potent, selective first-in-class catalytic inhibitor of METTL3 with IC50 of 16.9 nM, binds to the METTL3-METTL14 with Kd of 1.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | $898 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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STM2457 (STM-2457) is a highly potent, selective first-in-class catalytic inhibitor of METTL3 with IC50 of 16.9 nM, binds to the METTL3-METTL14 with Kd of 1.4 nM.
Treatment of STM2457 leads to reduced AML growth and an increase in differentiation and apoptosis.
STM2457 reduces m6A levels on known leukaemogenic mRNAs and decreasse in their expression consistent with a translational defect.
STM2457 impaired engraftment and prolonged survival in various mouse models of AML, specifically targeting key stem cell subpopulations of AML.
| M.Wt | 444.539 | |
| Formula | C25H28N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((6-(((cyclohexylmethyl)amino)methyl)imidazo[1,2-a]pyridin-2-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide |
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1. Yankova E, et al. Nature. 2021 May;593(7860):597-601.
2. Xu QC, et al. Oncogene. 2022 Jan 29. doi: 10.1038/s41388-022-02185-1.
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