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STX140

Chemical Structure : STX140

CAS No.: 401600-86-0

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STX140 (STX-140)

Catalog No.: PC-28770Not For Human Use, Lab Use Only.

STX140 is an orally bioavailable anti-angiogenic microtubule disruptor, shows promising anticancer potency both in vitro and in vivo, causes apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

STX140 is an orally bioavailable anti-angiogenic microtubule disruptor, shows promising anticancer potency both in vitro and in vivo, causes apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.

Physicochemical Properties

M.Wt 460.56
Formula C19H28N2O7S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Methoxyestradiol 3,17-O,O-bis-sulfamate

References

1. Newman SP, et al. Clin Cancer Res. 2008 Jan 15;14(2):597-606.

2. Newman SP, et al. Cancer Res. 2006 Jan 1;66(1):324-30.

3. Newman SP, et al. Br J Cancer. 2007 Dec 17;97(12):1673-82.

4. Meyer-Losic F, et al. PLoS One. 2013 Dec 6;8(12):e80305.

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