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Chemical Structure : STX3451
Catalog No.: PC-61251Not For Human Use, Lab Use Only.
A non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor, shows anti-proliferative activity against NCI 60 cell lines with mean GI50 of 50 nM.
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A non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor, shows anti-proliferative activity against NCI 60 cell lines with mean GI50 of 50 nM; induces apoptosis in human malignant peripheral nerve sheath tumour (MPNST) cell lines, inhibits both PI3 kinase and mTOR signalling pathways, selectively kills MPNST-derived cells, but also halts growth of other tumour-derived NF1 cell lines.
| M.Wt | 487.365 | |
| Formula | C19H23BrN2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shen YC, et al. Br J Cancer. 2015 Oct 20;113(8):1158-67.
2. Dohle W, et al. ChemMedChem. 2014 Aug;9(8):1783-93.
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