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Chemical Structure : SU11274
CAS No.: 658084-23-2
Catalog No.: PC-42829Not For Human Use, Lab Use Only.
SU11274 (PKI-SU11274) is a potent, selective, ATP-competitive c-Met kinase inhibitor with IC50 of 20 nM, >50-fold selectivity over Bcr-Abl, JAK2, PDGFβR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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SU11274 (PKI-SU11274) is a potent, selective, ATP-competitive c-Met kinase inhibitor with IC50 of 20 nM, >50-fold selectivity over Bcr-Abl, JAK2, PDGFβR.
SU11274 (PKI-SU11274) induces G(1) cell cycle arrest and apoptosis with increased Annexin V staining and caspase 3 activity, specifically regulates cell growth in TPR-MET-transformed BaF3 cells with IC50 of <3 uM.
SU11274 (PKI-SU11274) differentially affects the kinase activity and subsequent signaling of various mutant forms of Met (M1268T and H1112Y).
| M.Wt | 568.0869 | |
| Formula | C28H30ClN5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)- |
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1. Sattler M, et al. Cancer Res. 2003 Sep 1;63(17):5462-9.
2. Berthou S, et al. Oncogene. 2004 Jul 8;23(31):5387-93.
3. Ma PC, et al. Cancer Res. 2005 Feb 15;65(4):1479-88.
4. Jagadeeswaran R, et al. Cancer Res. 2006 Jan 1;66(1):352-61.
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