SU1349 | IKKα inhibitor | Probechem Biochemicals

Chemical Structure : SU1349

SU1349 (SU 1349)

Catalog No.: PC-22935Not For Human Use, Lab Use Only.

SU1349 is a potent, selective inhibitor of IKKα with Ki of 16 nM, >200-fold selective over IKKβ.

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Biological Activity

SU1349 is a potent, selective inhibitor of IKKα with Ki of 16 nM, >200-fold selective over IKKβ, selectively perturbs non-canonical NF-κB signalling whilst avoiding any significant impact upon the IKKβ-mediated canonical NF-κB pathway in cells.

Physicochemical Properties

M.Wt	432.49
Formula	C26H20N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-(2-(benzyloxy)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-indazol-3-amine

References

1. Christopher Riley, et al. Molecules. 2024 Jul 26;29(15):3515.

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SU1349 (SU 1349)

Biological Activity

Physicochemical Properties

References

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