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SUVN-502 mesylate hydrate

Chemical Structure : SUVN-502 mesylate hydrate

CAS No.: 1791396-45-6

SUVN-502 mesylate hydrate (SUVN502)

Catalog No.: PC-61522Not For Human Use, Lab Use Only.

SUVN-502 (SUVN502) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SUVN-502 (SUVN502) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM; shows high selectivity over 5-HT2A receptor and other 100 target sites; produces synergistic effects in extracellular levels of acetylcholine in the ventral hippocampus combined with donepezil and memantine; shows potential for treatment of Alzheimer's disease.

Alzheimer Disease

Phase 2 Clinical

Physicochemical Properties

M.Wt 688.62
Formula C23H34BrN3O10S3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-((2-bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole dimethanesulfonate hydrate

References

1. Nirogi R, et al. J Med Chem. 2017 Mar 9;60(5):1843-1859.

2. Nirogi R, et al. J Pharm Biomed Anal. 2017 Apr 14;145:423-430.

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