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Chemical Structure : SUVN-G3031 free base
Catalog No.: PC-35982Not For Human Use, Lab Use Only.
SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).
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SUVN-G3031 (Samelisant) free base is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).
SUVN-G3031 exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 µM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes.
SUVN-G3031 reverses (R)-α-methylhistamine induced dipsogenia in vivo.
| M.Wt | 373.497 | |
| Formula | C21H31N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nirogi R, et al. J Med Chem. 2019 Jan 10. doi: 10.1021/acs.jmedchem.8b01280.
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