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SW-044248

Chemical Structure : SW-044248

CAS No.: 522650-83-5

SW-044248 (SW 044248;SW044248)

Catalog No.: PC-45667Not For Human Use, Lab Use Only.

SW-044248 is a potent, selective inhibitor of Topoisomerase I (Topo I), inhibits Top I differently from camptothecin, shows selective toxicity for some NSCLC cell lines.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SW-044248 is a potent, selective inhibitor of Topoisomerase I (Topo I), inhibits Top I differently from camptothecin, shows selective toxicity for some NSCLC cell lines.

Physicochemical Properties

M.Wt 421.5153
Formula C22H23N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

Butanamide, 2-[(5-ethyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)thio]-N-(2-methoxyphenyl)-

References

1. Zubovych IO, et al. Mol Cancer Ther. 2016 Jan;15(1):23-36.

2. Kim HS, et al. Cell. 2013 Oct 24;155(3):552-66.

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