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Chemical Structure : SWE101
Catalog No.: PC-73058Not For Human Use, Lab Use Only.
SWE101 (SWE-101, SWE 101) is a potent, selective, in vivo active inhibitor of soluble epoxide hydrolase (sEH) phosphatase domain (sEH-P) with IC50 of 58 nM.
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SWE101 (SWE-101, SWE 101) is a potent, selective, in vivo active inhibitor of soluble epoxide hydrolase (sEH) phosphatase domain (sEH-P) with IC50 of 58 nM.
SWE101 showed no significantactivity against sEH-H activity, did not inhibit either the hydrolase or phosphatase activity of mouse sEH.
SWE101 is active in rats with favorable pharmacokinetics and revealed the involvement of sEH-P in LPA hydrolysis.
| M.Wt | 376.233 | |
| Formula | C19H15Cl2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kramer JS, et al. J Med Chem. 2019 Sep 26;62(18):8443-8460.
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