Saikosaponin B1

Chemical Structure : Saikosaponin B1

CAS No.: 58558-08-0

Catalog No.: PC-27756Not For Human Use, Lab Use Only.

Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anti-cancaer activty, inhibits tumor growth in medulloblastoma via inhibiting Hedgehog pathway through targeting Smoothened (SMO), inhibits GLI-luciferase activity in Shh Light II cells with IC50 of 241.8 nM, also is a potent modulator of Piezo1 channel, alleviates mitochondrial damage and apoptosis in osteoarthritic chondrocytes.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
50 mg	$298	In stock
100 mg		Get quote

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Biological Activity

Physicochemical Properties

M.Wt	780.98
Formula	C42H68O13
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-3,5-Dihydroxy-2-(((3S,4R,4aR,6aR,6bS,8S,8aS,14aR,14bS)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicen-3-yl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

References

1. Luo J, et al. J Nat Med. 2022 Jun;76(3):584-593.

2. Yang X, et al. Biochem Pharmacol. 2026 Aug 13;253(Pt 2):118360.

Saikosaponin B1

Biological Activity

Physicochemical Properties

References

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