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Chemical Structure : Sarcomere inhibitor W7
Catalog No.: PC-38788Not For Human Use, Lab Use Only.
Sarcomere inhibitor W7 is a small-molecule sarcomere Ca2+ desensitizer, decreases intact cardiac myocyte contractility in a Ca2+ transient amplitude-independent manner.
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Sarcomere inhibitor W7 is a small-molecule sarcomere Ca2+ desensitizer, decreases intact cardiac myocyte contractility in a Ca2+ transient amplitude-independent manner.
W7 binds to cardiac troponin C (cTnC) and decrease Ca2+-binding affinity, resulting in Ca2+ desensitization of the myofilament.
W7 reduces contractility in a Ca2+-independent manner in adult living cardiac myocytes.
W7 exihibits a rapid effect to correct contractile dysfunction in both acquired (alkalosis) and inherited (RCM) forms of hyper-Ca2+-sensitive states at the myocyte level and whole heart levels.
| M.Wt | 340.866 | |
| Formula | C16H21ClN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thompson BR, et al. Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H36-43.
2. Cai F, et al. Biochemistry. 2018 Nov 20;57(46):6461-6469.
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