Chemical Structure : SecA activator HSI6
CAS No.:
61516-45-8
SecA activator HSI6
(HSI#6)
Catalog No.: PC-26035Not For Human Use, Lab Use Only.
SecA activator HSI#6 is a small molecule, specific and allosteric activator of SecA dependent secretion, binds onto SecA and allosterically activates the translocase with AC50 of 3.76 uM, activates the soluble, membrane-bound and at-translocation-site SecA states.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SecA activator HSI#6 is a small molecule, specific and allosteric activator of SecA dependent secretion, binds onto SecA and allosterically activates the translocase with AC50 of 3.76 uM, activates the soluble, membrane-bound and at-translocation-site SecA states.
HSI#6 (10 uM) has barely an effect on the basal, stimulates the membrane ATPase by ~3folds and no effect on the translocation.
HSI#6 has not affect the in vitro activity of other enzyme as DnaK, Alkaline phosphatase.
HSI#6 affects all forms of the enzyme; soluble, membrane-bound and 'at-translocation'.
HSI#6 enhances SecA dependent preprotein secretion, in vivo and in vitro.
HSI#6 enhances ADP release from SecA.
HSI#6 activates the translocase by modulating the intrinsic dynamics of SecA.
Physicochemical Properties
|
M.Wt
|
340.68
|
|
Formula
|
C10H5ClF4N4OS
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
1-(3-chloro-4-fluorophenyl)-3-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)urea
|
References
1. Sedky H, et al. Commun Biol. 2026 Feb 6. doi: 10.1038/s42003-026-09623-w.
Contact Us
sales@probechem.com
