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Chemical Structure : Selumetinib
CAS No.: 606143-52-6
Catalog No.: PC-45849Not For Human Use, Lab Use Only.
Selumetinib (ARRY-142886, AZD-6244) highly potent and selective, ATP-uncompetitive inhibitor of MEK1/2 with IC50/Ki of 14.1 nM/22.6 nM for MEK1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $178 | In stock | |
| 100 mg | $288 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Selumetinib (ARRY-142886, AZD-6244) highly potent and selective, ATP-uncompetitive inhibitor of MEK1/2 with IC50/Ki of 14.1 nM/22.6 nM for MEK1.
Selumetinib (ARRY-142886, AZD-6244) shows no activity against other 40 serine/threonine and tyrosine kinases.
Selumetinib (ARRY-142886, AZD-6244) inhibits cellular ERK1/2 phosphorylation (IC50<40 nM), suppresses growth inhibition of several cell lines containing B-Raf and Ras mutations (IC50=59-473 nM).
Selumetinib (ARRY-142886, AZD-6244) causes growth of HT-29 xenograft tumors in nude mice.
| M.Wt | 457.6814 | |
| Formula | C17H15BrClFN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl- |
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1. Huynh H, et al. Mol Cancer Ther. 2007 Jan;6(1):138-46.
2. Yeh TC, et al. Clin Cancer Res. 2007 Mar 1;13(5):1576-83.
3. Davies BR, et al. Mol Cancer Ther. 2007 Aug;6(8):2209-19.
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