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Chemical Structure : Sephin 1
CAS No.: 951441-04-6
Catalog No.: PC-62320Not For Human Use, Lab Use Only.
Sephin 1 (Icerguastat, NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $368 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Sephin 1 (Icerguastat, NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex.
Sephin 1 prolongs eIF2α phosphorylation after stress, attenuates the expression of stress genes such as CHOP, and protects cells from cytotoxic ER stress; lacks any measurable α2-adrenergic agonist activity in a cell-based assay, in contrast to Guanabenz.
Sephin 1 safely prevents the motor, morphological, and molecular defects in mice.
| M.Wt | 196.64 | |
| Formula | C8H9ClN4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide |
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1. Das I, et al. Science. 2015 Apr 10;348(6231):239-42.
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