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Chemical Structure : Serdemetan
CAS No.: 881202-45-5
Catalog No.: PC-42840Not For Human Use, Lab Use Only.
Serdemetan (JNJ 26854165) is an anticancer agent that inhibits the function of the E3 ligase HDM2, dose-dependently inhibits proliferation in both wild-type and mutant p53 cell lines with IC50 of 0.25-3 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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Serdemetan (JNJ 26854165) is an anticancer agent that inhibits the function of the E3 ligase HDM2, dose-dependently inhibits proliferation in both wild-type and mutant p53 cell lines with IC50 of 0.25-3 uM.
Serdemetan (JNJ 26854165) induces p53-mediated apoptosis in acute leukemia cells with wild-type p53, accelerates the proteasome-mediated degradation of p21 and antagonizes the transcriptional induction of p21 by p53, induces S-phase delay and upregulates E2F1 expression in p53 mutant cells.
Serdemetan (JNJ 26854165) demonstrates radiosensitizing activity in vitro and in tumor xenografts.
| M.Wt | 328.4103 | |
| Formula | C21H20N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,4-Benzenediamine, N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl- |
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1. Kojima K, et al. Mol Cancer Ther. 2010 Sep;9(9):2545-57.
2. Tabernero J, et al. Clin Cancer Res. 2011 Oct 1;17(19):6313-21.
3. Chargari C, et al. Cancer Lett. 2011 Dec 22;312(2):209-18.
4. Jones RJ, et al. J Pharmacol Exp Ther. 2013 Sep;346(3):381-92.
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