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Chemical Structure : Shield-1
CAS No.: 914805-33-7
Catalog No.: PC-60184Not For Human Use, Lab Use Only.
Shield-1 is a cell-permeable FKBP ligand that is designed to protect an otherwise unstable protein domain from degradation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $178 | In stock | |
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Shield-1 is a cell-permeable FKBP ligand that is designed to protect an otherwise unstable protein domain from degradation.
Shield-1 binds tightly to FKBP, induces rapid and processive degradation of the LID domain and any fused partner protein.
| M.Wt | 748.9 | |
| Formula | C42H56N2O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl) propyl 1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate |
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1. Banaszynski, et al. Cell. 2006 Sep 8; 126(5):995-1004.
2. Rodriguez S, et al. Chem Biol. 2012 Mar 23;19(3):391-8.
3. Bonger KM, et al. Nat Chem Biol. 2011 Jul 3;7(8):531-7.
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