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Chemical Structure : Shikonin
CAS No.: 517-89-5
Catalog No.: PC-21476Not For Human Use, Lab Use Only.
Shikonin is a specific inhibitor of the IKKβ/NEMO complex PPI with IC50 of 170 nM, blocks the complex formation in vitro, in cell culture and in animal models.
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|---|---|---|---|
| 50 mg | $148 | In stock | |
| 100 mg | $228 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Shikonin is a specific inhibitor of the IKKβ/NEMO complex PPI with IC50 of 170 nM, blocks the complex formation in vitro, in cell culture and in animal models.
Shikonin possesses various physiological and pharmacological properties, including anti-inflammatory, wound healing, and anti-cancer effects.
Shikonin suppresses the malignant phenotypes of colorectal cancer cells in vitro and in vivo, decreases the protein levels Cyclin E1/D1, CDK4 and MMP2/9, while increasing the levels of cleaved caspases 3 and 9, cleaved PARP, and TIMP.
Shikonin shows no effects on the upstream regulators of IKKβ/NEMO complex.
Shikonin effectively impairs NEMO/IKKβ interaction with IC50 of 231.03 nM in fluorescence resonance energy transfer (FRET) assays.
Shikonin is a natural product and is a bioactive constituent of Lithospermum erythrorhizon, which has a long history of more than 2000 years of use as a Chinese medicinal herb known as zicao.
| M.Wt | 288.3 | |
| Formula | C16H16O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione |
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1. Zhenlong Yu, et al. Signal Transduction and Targeted Therapy volume 7, Article number: 71 (2022)
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