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Chemical Structure : Simeprevir
CAS No.: 923604-59-5
Catalog No.: PC-42480Not For Human Use, Lab Use Only.
A potent, orally available inhibitor of HCV NS3/4A protease with Ki of 0.36 nM, replicon EC50 of 7.8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 50 mg | $720 | In stock | |
| 100 mg | $1200 | In stock |
Bulk size, bulk discount!
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A potent, orally available inhibitor of HCV NS3/4A protease with Ki of 0.36 nM, replicon EC50 of 7.8 nM; inhibits NS3/4A proteases of genotypes 1a and 1b with Ki of 0.5 and 0.4 nM, shows synergistic effect with α-Interferon and an NS5B inhibitor in the replicon model and additive with ribavirin; exerts favorable pharmacokinetic profile and antiviral activity in vivo.
HCV Infection
Approved
| M.Wt | 749.9391 | |
| Formula | C38H47N5O7S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, N-(cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, (2R,3aR,1 |
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1. Raboisson P, et al. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8.
2. Lin TI, et al. Antimicrob Agents Chemother. 2009 Apr;53(4):1377-85.
3. Lenz O, et al. Antimicrob Agents Chemother. 2010 May;54(5):1878-87.
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