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Chemical Structure : Simufilam hydrochloride
Catalog No.: PC-72846Not For Human Use, Lab Use Only.
Simufilam hydrocloride (PTI-125) is a small molecule targeting scaffolding protein filamin A (FLNA), preferentially binds altered FLNA and restores its native conformation.
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Simufilam hydrochloride (PTI-125) is a small molecule targeting scaffolding protein filamin A (FLNA), preferentially binds altered FLNA and restores its native conformation.
PTI-125 restores receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
PTI-125 reduces tau hyperphosphorylation, aggregated Aβ42 deposition, neurofibrillary tangles, and neuroinflammation in triple-transgenic (3xTg) Alzheimer's disease (AD) mice.
PTI-125 alleviates neuronal abnormalities and reduced seizure frequency in mice modeling TSC and FCDII with mutations in PI3K-ras homolog enriched in brain (Rheb) pathway genes.
| M.Wt | 295.811 | |
| Formula | C15H22ClN3O | |
| Appearance | Solid | |
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1. Zhang L, et al. Sci Transl Med. 2020 Feb 19;12(531):eaay0289.
2. Wang HY, et al. Neurobiol Aging. 2017 Jul;55:99-114.
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