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Chemical Structure : Siomycin A
Catalog No.: PC-63570Not For Human Use, Lab Use Only.
Siomycin A (NSC 285116) is an antibiotic thiazole inhibitor of the oncogenic transcription factor FOXM1, down-regulates the transcriptional activity as well as the protein and mRNA abundance of FoxM1.
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Siomycin A (NSC 285116) is an antibiotic thiazole inhibitor of the oncogenic transcription factor FOXM1, down-regulates the transcriptional activity as well as the protein and mRNA abundance of FoxM1.
Siomycin A (NSC 285116) represses the downstream target genes of FoxM1, such as Cdc25B, Survivin, and CENPB.
Siomycin A (NSC 285116) reduces anchorage-independent growth of cells in soft agar, selectively induces apoptosis in transformed but not normal cells.
| M.Wt | 1648.84 | |
| Formula | C71H81N19O18S5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Radhakrishnan SK, et al. Cancer Res. 2006 Oct 1;66(19):9731-5.
2. Joshi K, et al. Stem Cells. 2013 Jun;31(6):1051-63.
3. Briest F, et al. Oncotarget. 2015 Apr 10;6(10):8185-99.
4. Penke LR, et al. J Clin Invest. 2018 May 7. pii: 87631. doi: 10.1172/JCI87631.
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