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SirReal1

Chemical Structure : SirReal1

CAS No.: 801227-82-7

SirReal1 (SirReal 1)

Catalog No.: PC-60124Not For Human Use, Lab Use Only.

SirReal1 is novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 3.745 uM, displays no inhibitory activity against Sirt1 and Sirt 3 (IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SirReal1 is novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 3.745 uM, displays no inhibitory activity against Sirt1 and Sirt 3 (IC50>100 uM).

    Physicochemical Properties

    M.Wt 370.489
    Formula C18H18N4OS2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(5-benzylthiazol-2-yl)-2-((4,6-dimethylpyrimidin-2-yl)thio)acetamide

    References

    1. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6.

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